|
|
Digital Library of the
European Council for Modelling and Simulation |
|
Title: |
Numerical Simulation Of Biochemical Behaviour
Of Biosensors With
Perforated Membrane |
|
Authors: |
Romas Baronas |
|
Published in:
|
ECMS
2007 Proceedings Edited
by: Ivan Zelinka, Zuzana Oplatkova, Alessandra Orsoni ISBN:
978-0-9553018-2-7 Doi: 10.7148/2007 21st European
Conference on Modelling and Simulation, Prague, June
4-6, 2007 |
|
Citation
format: |
Baronas, R. (2007). Numerical Simulation
Of Biochemical Behaviour Of Biosensors With
Perforated Membrane. ECMS 2007 Proceedings edited by: I. Zelinka,
Z. Oplatkova, A. Orsoni (pp. 214-217). European Council for
Modeling and Simulation. doi:10.7148/2007-0214. |
|
DOI: |
http://dx.doi.org/10.7148/2007-0214 |
|
Abstract: |
A
two-dimensional-in-space mathematical model of amperometric
biosensors with selective and perforated membranes has been proposed and
analyzed. The model involves the geometry of holes partially or fully filled
with an enzyme. The model is based on a system of the reaction-diffusion
equations containing a nonlinear term related to the Michaelis-Menten
enzymatic reaction. Using numerical simulation of the biosensor action, the
influence of the geometry of the holes as well as of the filling level of the
enzyme in the holes on the biosensor response was investigated. The numerical
simulation was carried out using the finite difference technique. The
calculation demonstrated that the effect of the filling level on the
biosensor response decreases with decrease of radius of the holes. |
|
Full
text: |
|
