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Digital Library of the
European Council for Modelling and Simulation |
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Title: |
Extended Neonatal Metabolic Screening By Tandem Mass Spectrometry:
Models And Simulation Of Alternative Management Solutions |
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Authors: |
Arturo Liguori, Giorgio Romanin-Jacur |
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Published in:
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(2014).ECMS 2014 Proceedings edited
by: Flaminio Squazzoni,
Fabio Baronio, Claudia Archetti,
Marco Castellani European Council for
Modeling and Simulation. doi:10.7148/2014 ISBN:
978-0-9564944-8-1 28th
European Conference on Modelling and Simulation, Brescia,
Italy, May 27th – 30th,
2014 |
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Citation
format: |
Arturo
Liguori, Giorgio Romanin-Jacur
(2014). Extended Neonatal Metabolic Screening By
Tandem Mass Spectrometry: Models And Simulation Of Alternative Management
Solutions, ECMS 2014 Proceedings edited by: Flaminio
Squazzoni, Fabio Baronio,
Claudia Archetti, Marco Castellani European
Council for Modeling and Simulation. doi:10.7148/2014-0193 |
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DOI: |
http://dx.doi.org/10.7148/2014-0193 |
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Abstract: |
Neonatal metabolic screening
aims at identifying newborns with severe metabolic pathologies in order to promote
appropriate interventions to avoid or to improve adverse outcomes. Tandem
Mass Spectrometry permits, from a blood drop, collected on a blotting paper
by a puncture on the heel, to measure a lot of metabolites according to their
mass; this method can identify more than 30 metabolites, each of which is a
potential marker of a hereditary metabolic disease. The large amount of
available information and the difficulty in correctly interpreting them in a
short time, compatible with the exigencies of newborns, imposes to find an
optimal management of structures devoted to perform the related tests. In the
paper four different solutions, based on different utilizations of a cluster
of two or more test structures, are examined and evaluated. A simulation
model, coded in language Arena, has been built to get numerical results; such
a model may be usefully employed to compare the effects of different
solutions for an actual situation and to give a correct dimensioning to the
chosen solution. |
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