Digital Library

of the European Council for Modelling and Simulation



Modelling A Peroxidase-Based Fluorescent Biosensor


Evelina Gaidamauskaitė, Romas Baronas

Published in:


ECMS 2008 Proceedings

Edited by: Loucas S. Louca, Yiorgos Chrysanthou, Zuzana Oplatkova, Khalid Al-Begain


ISBN: 978-0-9553018-6-5

Doi: 10.7148/2008


22nd European Conference on Modelling and Simulation,

Nicosia, June 3-6, 2008


Citation format:

Gaidamauskaite, E., & Baronas, R. (2008). Modelling A Peroxidase-Based Fluorescent Biosensor. ECMS 2008 Proceedings edited by: L. S. Louca, Y. Chrysanthou, Z. Oplatkova, K. Al-Begain (pp. 152-156). European Council for Modeling and Simulation. doi:10.7148/2008-0152.



The paper presents a one-dimensional-in-space mathem- atical model of a peroxidase-based fluorescent biosensor. The mathematical model is based on a system of non- linear reaction diffusion equations. The problem was solved numerically using finite difference technique. The model was used to study the effect of biosensor paramet- ers, namely the thickness of the enzyme layer and the outer substrate concentration, on the response of the bi- osensor and it’s sensitivity. The performed calculations showed a complex influence of the substrate and hydro- gen peroxide concentrations.

Full text: