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Digital Library of the
European Council for Modelling and Simulation |
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Title: |
Modelling Tumor-Immune Systems With
Cell-DEVS |
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Authors: |
Rhys Goldstein, Gabriel Wainer |
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Published in:
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ECMS
2008 Proceedings Edited
by: Loucas S. Louca, Yiorgos Chrysanthou, Zuzana Oplatkova, Khalid Al-Begain ISBN:
978-0-9553018-6-5 Doi: 10.7148/2008 22nd
European Conference on Modelling and Simulation, Nicosia, June
3-6, 2008 |
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Citation
format: |
Goldstein, R. (2008). Modelling Tumor-Immune Systems With Cell-DEVS. ECMS 2008
Proceedings edited by: L. S. Louca, Y. Chrysanthou, Z. Oplatkova, K. Al-Begain (pp. 329-335).
European Council for Modeling and Simulation. doi:10.7148/2008-0329 |
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DOI: |
http://dx.doi.org/10.7148/2008-0329 |
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Abstract: |
Cell-DEVS,
an extension of the DEVS formalism, is used to model tumor-immune systems
that involve grow- ing tumors interacting with
immune cells. Tumors can be regarded as a core of necrotic cells, surrounded
by dormant cells, surrounded in turn by proliferative cells. The growth of a
tumor is effected by the division of its proliferative cells, but inhibited
by nearby immune cells. We present a Cell-DEVS model representing a tumor-
immune system. The use of Cell-DEVS is advantageous as it facilitates the
formal specification and reuse of cel- lular models. The Cell-DEVS model was implemented and
tested using the CD++ toolkit. Simulation results in- dicate
that, in a qualitative sense, the desired behaviour
of tumors and immune cells was captured. |
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