Digital Library

of the European Council for Modelling and Simulation



Modelling Tumor-Immune Systems With Cell-DEVS


Rhys Goldstein, Gabriel Wainer

Published in:


ECMS 2008 Proceedings

Edited by: Loucas S. Louca, Yiorgos Chrysanthou, Zuzana Oplatkova, Khalid Al-Begain


ISBN: 978-0-9553018-6-5

Doi: 10.7148/2008


22nd European Conference on Modelling and Simulation,

Nicosia, June 3-6, 2008


Citation format:

Goldstein, R. (2008). Modelling Tumor-Immune Systems With Cell-DEVS. ECMS 2008 Proceedings edited by: L. S. Louca, Y. Chrysanthou, Z. Oplatkova, K. Al-Begain (pp. 329-335). European Council for Modeling and Simulation. doi:10.7148/2008-0329



Cell-DEVS, an extension of the DEVS formalism, is used to model tumor-immune systems that involve grow- ing tumors interacting with immune cells. Tumors can be regarded as a core of necrotic cells, surrounded by dormant cells, surrounded in turn by proliferative cells. The growth of a tumor is effected by the division of its proliferative cells, but inhibited by nearby immune cells. We present a Cell-DEVS model representing a tumor- immune system. The use of Cell-DEVS is advantageous as it facilitates the formal specification and reuse of cel- lular models. The Cell-DEVS model was implemented and tested using the CD++ toolkit. Simulation results in- dicate that, in a qualitative sense, the desired behaviour of tumors and immune cells was captured.

Full text: